Tesofensine is a triple monoamine reuptake inhibitor (MRI) that modulates dopaminergic, noradrenergic, and serotonergic neurotransmission. It selectively inhibits the presynaptic reuptake of dopamine (DA), norepinephrine (NE), and serotonin (5-HT), influencing neurotransmitter availability and receptor interactions. This compound undergoes hepatic metabolism via cytochrome P450 enzymes (CYP3A4), producing active metabolites with prolonged systemic activity.
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